Early Online – Page 6 – Asian Pacific Journal of Allergy and Immunology

May 30, 2022

The implementation of pediatric asthma guidelines including self-assessment of the level of confidence and accessibility of medical supplies necessary for asthma management from the perspectives of multidisciplinary care teams

Asthma control in Thai children is not yet satisfactory. Direct observation of the clinical practice for health care professionals (HCPs) in asthma clinic is essential.

asthma exacerbations, asthma guideline implementation, health care professionals, medical supplies, pediatric

May 30, 2022

Skin necrosis following local anesthetic: Same presentation for two different diagnoses

Local anesthetics (LA) are widely used in medicine and are generally well tolerated. Although most adverse reactions are nonallergic, LA are a frequent reason for allergy consultation.

drug allergy evaluation, Drug hypersensitivity, local anesthetic hypersensitivity, local anesthetics, skin necrosis

May 30, 2022

Asia-Pacific survey of physicians’ perceptions and managements of chronic rhinosinusitis

The diagnosis and management of patients with chronic rhinosinusitis (CRS) may vary between otolaryngologists and allergists. Moreover, the adherence of different practitioners to European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS)2020 guideline recommendations has not been previously ascertained in Asia-Pacific regions.

allergists, chronic rhinosinusitis, diagnosis, otolaryngologists, treatment

March 14, 2022

Adverse drug reactions of montelukast and pranlukast: Analysis of the Korea database

Leukotriene receptor antagonists are recommended to treat asthma and allergic rhinitis. Although they had been used for a long time, recent studies have reported neuropsychiatric adverse drug reactions are associated with montelukast.

depression, insomnia, Leukotriene receptor antagonist, neuropsychiatric events, sleep disorder

March 14, 2022

Maintained disease control and steroid-sparing effect of subcutaneous immunotherapy in allergic rhinitis and asthma

Allergen immunotherapy is the only currently available treatment strategy that modifies the immune response to the causative allergen and induces clinical improvement and a steroid-sparing effect.

Allergen immunotherapy, Allergic rhinitis, Asthma, efficacy, inhaled steroid, intranasal steroid, steroid sparing

March 14, 2022

N-acetylcysteine potentiates the tumor cytotoxicity of cytokine-induced killer cells

Cytokine-induced killer (CIK) cells are an ex vivo expanded heterogeneous population of natural killer (NK)-like T cells that can exert potent MHC-unrestricted antitumor activity. A number of pre-clinical and clinical studies have demonstrated that CIK cells can serve as a safe and potent immunotherapy of malignant tumors. N-acetylcysteine (NAC) has been demonstrated to enhance the T-cell functions by increasing their proliferation and cytokine production.

Antitumor effect, Cancer immunotherapy, cytokine-induced killer cells, Cytotoxicity, N-acetylcysteine

March 14, 2022

Anxiety and depression are associated with reduced quality of life and increased cough severity in chronic cough

Early Online, Original Article Anxiety and depression are associated with reduced quality of life and increased cough severity in chronic cough Yiting Li,1 Chao Cao,1 Yunxin Ji,2 Suling Xu3 1 Department of Respiratory Medicine, Ningbo First Hospital, Ningbo, Zhejiang,...

Anaphylaxis, anxiety, Chronic Cough, depression, Quality of life

March 14, 2022

Thrombosis with thrombocytopenia after the second ChAdOx1 nCoV-19 vaccination: A possible immunological mechanism independent of anti-platelet factor 4 antibody

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a distinctive syndrome characterized by unusual site thrombosis accompanied by thrombocytopenia following adenoviral vector vaccines against severe acute respiratory syndrome coronavirus 2. Platelet-activating anti-platelet factor 4-dependent antibodies (anti-PF4 Abs) have been identified as pathogenic antibodies in almost all patients.

adenoviral vector, antibody, platelet factor 4, thromboembolism, vaccine

January 4, 2022

Invariant Natural Killer T (iNKT) cells response in human melioidosis

Melioidosis is an infectious disease caused by Burkholderia pseudomallei. In infected mice, IFN-γ can provide protection against B. pseudomallei infection. Invariant Natural Killer T (iNKT) cells are a subpopulation of T lymphocytes, activated by recognition of glycolipid ligands such as α-Galactosylceramide presented by CD1d, produce and secrete several cytokines, including IFN-γ and IL-4. The response of iNKT cells in human melioidosis was then investigated.

activation, Burkholderia pseudomallei, human infection, iNKT cells, Melioidosis

January 4, 2022

Role of interleukin 5-induced eosinophils in interleukin 33-triggered airway inflammation in mice

Interleukin (IL)-5 is essential for allergen induced eosinophilic airway inflammation, but not activation of T helper type 2 (Th2) cells in the lung. Although an excessive Th2 reaction is observed without IL-5 signaling, the mechanisms have remained unknown.

airway inflammation, eosinophil, IL-33, IL-5Rα-/- mice, ILC2