Small airway dysfunction and associated clinical characteristicsin severe asthma under omalizumab and mepolizumab treatment
Small airway dysfunction (SAD) plays a critical role in the pathophysiology of asthma.
Differences in asthma-related outcomesby anti-IL-5 biologics, omalizumab, and dupilumabbased on blood eosinophil counts
Selecting optimal biologics based on type 2 biomarkers has been of interest in severe asthma treatment. However, few direct biomarker stratification-based comparisons have been made.
Bronchoalveolar lavage fluid cytokines and chemokines changesafter bronchial thermoplasty in severe asthma
Bronchial thermoplasty (BT) is a non-pharmacological intervention in severe asthma with a well-known mechanism of reducing airway smooth muscle. However, its effect on airway inflammation remains uncertain.
Mepolizumab improved airway hyperresponsiveness in a patient with allergic bronchopulmonary aspergillosis
Allergic bronchopulmonary aspergillosis (ABPA) is a severe type of asthma characterized by hypersensitivity to Aspergillus fumigatus and lung infiltration with eosinophilia. The central pathogenesis of asthma is airway hyperresponsiveness (AHR), with eosinophils playing a critical role. Anti-interleukin (IL)-5 antibody therapy has been recently introduced to treat severe asthma, which reportedly inactivates and reduces eosinophil count. A recent case series highlighted the improvement in asthmatic symptoms associated with ABPA, but previous reports failed to demonstrate any improvement in AHR.
Clinical characteristics and treatment outcomes of severe asthma patients with a history of multiple biologic drugs use
Asthma control has been shown to improve after clinical use of molecular-targeted biologic drugs. Although most patients have shown favorable responses to biologic drugs, some individuals need to switch to another biologic drug. To date, limited data are available regarding patients who received multiple biologic drugs.
Is mold sensitization associated with severe asthma exacerbation in children?
Mold sensitization has been reported as a factor associated with severe asthma exacerbation (SAE).
Risk factors for poor adherence to inhaled corticosteroid therapy in patients with moderate to severe asthma
Poor adherence to inhaled corticosteroid (ICS) therapy is a common reason for worsened asthma control.