Patterns of food allergen sensitization and co-sensitizationin Jordan: A laboratory-based analysis
Food allergy is an increasing global health concern, yet laboratory-based data on food allergen sensitization in Jordan remain limited.
Small airway dysfunction and associated clinical characteristicsin severe asthma under omalizumab and mepolizumab treatment
Small airway dysfunction (SAD) plays a critical role in the pathophysiology of asthma.
Reducing penicillin allergy mislabelling:A one-day structured training program improves nurses’ knowledge and self-reported confidence in allergy assessment and skin testing
Penicillins are the most commonly prescribed antibiotics; however, penicillin allergy (PA) labels are highly prevalent and often inaccurate, leading to suboptimal antibiotic selection use. In Mainland China, PA mislabeling is exacerbated by inappropriate penicillin skin testing (PST) practices. Nurses play a crucial role in assessing and labeling suspected PA, but the lack of systematic, evidence-based training limits their ability to address mislabeling effectively.
A multicenter study of crisaborole use in pediatric patients with atopic dermatitis in real-world setting in Thailand
Increasing evidence supports the efficacy of crisaborole in atopic dermatitis (AD). Ethnic differences in AD endotypes may influence treatment outcomes, while data in Southeast Asian children remain limited.
Evaluation of diagnostic approach and clinical outcomesin children with suspected beta-lactam allergy
Beta-lactams (BLs) are commonly implicated in hypersensitivity reactions among children. However, majority of self-reported BL allergies may be viral exanthems and antibiotics side effects. International guidelines have recommended de-labelling BL allergies in children with delayed mild hypersensitivity reactions via direct drug provocation tests (DPTs) without prior skin testing. However, studies on the safety of direct DPTs in Asia remain limited.
Drug persistence of omalizumab, cyclosporine,and hydroxychloroquinein antihistamine-refractory chronic spontaneous urticaria: A biomarker-stratified real-world study
Real-world comparative data on alternatives to omalizumab for antihistamine-refractory chronic spontaneous urticaria (CSU) are limited, particularly in resource-constrained Asia-Pacific settings.
External validation of the PEN-FAST clinical decision rulein children with reported penicillin allergy: A pediatric cohort study
Although penicillin allergy is frequently reported, the majority of labeled patients do not have confirmed hypersensitivity upon formal evaluation. The PEN-FAST clinical decision rule was developed to identify adults at low risk of true penicillin allergy; however, evidence supporting its performance in children remains limited.
Association between exercise habits including exercise partnerand allergic rhinitis in a Japanese population
Evidence on the association between physical activity (PA) and allergic rhinitis (AR) remains
inconsistent. While the prevalence of AR was high in Japan, no epidemiological study regarding this issue has been
conducted.
Superior magnitude and durability of hybrid immunityfollowing SARS-CoV-2 infection
The emergence of the SARS-CoV-2 Delta variant necessitated examining hybrid immunity (vaccination-
plus-infection) to optimize boosting strategies. We analyzed the kinetics, magnitude, and durability of anti-spike receptor binding domain immunoglobulin G (Anti-sRBD IgG) following Delta infection.
Analysis of daily aspirin intake on platelet-associated factors and aggregation in nonsteroidal anti-inflammatory drugexacerbated respiratory disease: A cross-sectional study
Nonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (N-ERD) is a
clinical syndrome characterized by chronic rhinosinusitis with nasal polyposis (CRSwNP), adult-onset asthma and hypersensitivity to NSAIDs. Long-term aspirin treatment after desensitization (ATAD) is used for clinical improvement in N-ERD patients. However, information on the potential effect of ATAD on the platelet-neutrophil aggregates (PNA) level in N-ERD patients is highly limited.