Children – Asian Pacific Journal of Allergy and Immunology

April 5, 2026

Effects of subcutaneous and sublingual allergen immunotherapyon immune responses in children with bronchial asthma

Allergic asthma in children significantly impacts quality of life, and immunotherapy, including subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT), has emerged as an effective treatment. However, their comparative immunological mechanisms remain unclear.

Asthma, Children, Inhaled corticosteroids, subcutaneous immunotherapy, Sublingual immunotherapy

April 5, 2026

Efficacy and safety of biologics in children and adolescents with eosinophilic asthma: A systematic review and meta-Analysis

Eosinophilic asthma is a severe phenotype in pediatrics, often refractory to conventional therapy. Biologic agents targeting Type 2 inflammatory pathway are increasingly used in children and adolescents.

adolescents, Children, Eosinophilic asthma, monoclonal antibodies, type 2 inflammation

February 12, 2025

Cost-effectiveness of salbutamol via metered-dose inhaler with spacers versus nebulizers in childrenwith asthma exacerbation in middle income country

Previous studies have demonstrated that salbutamol administration via metered-dose inhaler with spacer (MDI-S) is as effective as using a jet nebulizer (NEB) for treating children experiencing asthma exacerbation. However, a paucity of research focuses on the direct medical costs associated with each mode of salbutamol administration for asthma exacerbation.

Acute asthma, Aerosol therapy, Children, Direct medical cost, ICER

April 8, 2024

Pulmonary function characteristics in childrenwith suspected asthma: implications for asthma diagnosis

In children suspected of asthma, diagnosis is confirmed via variable expiratory airflow limitation. However, there is no single gold standard test for diagnosing asthma.

Asthma, Children, diagnosis, paediatric, spirometry

January 14, 2024

Anaphylaxis in children: Effect of age and atopic status

Anaphylaxis is a life-threatening allergic reaction with rising incidence worldwide. Young children’s limited ability to express symptoms adds unique diagnostic challenges.

adrenaline, Anaphylaxis, atopy, Children, young

January 14, 2024

Atmospheric environment and persistence of pediatricasthma: A population-based cohort study

Asthma is a heterogeneous disease with different outcomes. For children with asthma at the age of 7 years, 67–75% are symptom-free as adults. Data on the important link between childhood and adult asthma are sparse.

air pollution, Asthma, Children, National Claims Data, Persistence

January 14, 2024

Characterization of gut microbiome profile in childrenwith confirmed wheat allergy

Food allergies pose serious health risks, including life-threatening anaphylactic reactions, increased morbidity, and reduced quality of life. Wheat allergy is a common concern in Asia. There is growing interest in understanding the potential association between dysregulation of the gut microbiome and the development of food allergies.

Anaphylaxis, Children, gut microbiome, urticaria, wheat allergy

October 25, 2023

Global COVID-19 vaccination in infants and children:Effectiveness, safety, and challenges

COVID-19 Vaccines, which include mRNA and inactivated vaccines, have been proven effective and safe for infants and children aged more than six months in reducing the severity of the disease, hospitalization, multisystem inflammatory syndrome in children, and death.

Children, COVID-19 vaccines, infants, SARS-CoV-2

April 23, 2023

The natural history of childhood-onset nonallergic rhinitis; a long-term follow-up study

Non-allergic rhinitis (NAR) is characterized by symptoms of nasal inflammation without allergic sensitization. The long-term outcome of NAR in children is poorly defined.

Allergic rhinitis, childhood-onset nonallergic rhinitis, Children, natural history, nonallergic rhinitis, Sensitization

July 26, 2021

The relationship between the rs4986791 variant of the TLR4 gene and the severity of bronchial asthma in children

Toll-like receptor 4 (TLR4) is an important receptor for lipopolysaccharide and lipid A, components of gram-negative bacteria. At present, a variant in TLR4 has been shown to be associated with asthma, but it has not been reported whether variants in TLR4 are associated with bronchial asthma in children.

bronchial asthma, Children, TLR4, variant