Original Article – Page 10 – Asian Pacific Journal of Allergy and Immunology

November 2, 2021

Severe allergic asthma: Does alexithymia interfere with omalizumab treatment outcome?

Alexithymia is among psychological factors reported to interfere with asthma management. Severe allergic asthma (SAA) is characterized by uncontrolled asthma despite maximal standard pharmacological treatment which can benefit from an add-on treatment with Omalizumab, an anti-IgE monoclonal antibody.

alexithymia, Allergy, Asthma, Omalizumab, Quality of life

September 20, 2021

Eosinophilia, asthma, NERD and the use of oral corticosteroids predict uncontrolled chronic rhinosinusitis with nasal polyps after surgery

Severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP) is a challenging condition to treat. The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 (EPOS2020) has the following criteria when considering biological therapy for severe uncontrolled CRSwNP: eosinophilia, need for oral corticosteroids (OCS), symptom score, loss of sense of smell and co-morbid asthma.

Asthma, chronic rhinosinusitis, computed tomography, Eosinophilia, nasal polyp, sinusitis

September 20, 2021

The role of anti-elastin antibodies in a mouse model of asthma

The role of anti-elastin antibody (Ab) in the lung is unclear, although they may be involved in chronic obstructive pulmonary disease (COPD). Recently, increased anti-elastin Ab levels were reported in asthma.

airway remodeling, Anti-elastin antibodies, Asthma, Eosinophils, TGF-β

September 20, 2021

Direct healthcare cost comparison of Fluticasone propionate/Salmeterol vs Budesonide/Formoterol Maintenance And Reliever Therapy for moderate/severe asthma: Results from Thailand

Inhaled corticosteroid/long-acting β2-agonist (ICS/LABA) for moderate/severe asthma i.e. regular Fluticasone propionate/Salmeterol (FP/Salm) with as-needed short acting beta-2 agonist (SABA) or ICS/Formoterol Maintenance And Reliever Therapy (MART) are the recommended options.

Asthma, Budesonide/Formoterol Maintenance And Reliever Therapy, Fluticasone propionate/Salmeterol, ICS/LABA, MART, Thailand

September 20, 2021

Characteristics of allergic proctocolitis in early infancy; accuracy of diagnostic tools and factors related to tolerance development

We aimed to overview clinical characteristics of FPIAP with the results of diagnostic tools like APT, SPT and fecal calprotectin levels and the factors associated with tolerance development.

allergic proctocolitis, atopy patch test, bloody stools, cow’s milk allergy, food allergy

September 20, 2021

Synergy of interleukin-4 and interferon-γ in arginase-1 production in RAW264.7 macrophages

Interferon (IFN)-γ and interleukin (IL)-4 are considered to be important factors to regulate immune responses. Although the effects of IFN-γ or IL-4 on macrophage functions are well established, their cooperative action is not fully understood.

Arginase-1, interferon-γ, interleukin-4, macrophages, programmed death ligand 2

July 26, 2021

Validity and reliability of the Indonesian version of the Chronic Urticaria Quality of Life Questionnaire (CU-Q2oL)

Assessment of quality of life is needed to assess therapeutic response. There is currently no instrument available for assessing the quality of life of chronic urticaria patients in Indonesia. CU-Q2oL is a specific questionnaire for chronic urticaria that was first developed in Italian. Validity and reliability tests are important to ensure that the language or term used are appropriate to the local culture and there is no change in the validity and reliability of the questionnaire.

Chronic Urticaria, CU-Q2oL, Quality of life, Reliability, Validation

July 26, 2021

Comparison of perennial and preseasonal allergoid immunotherapy in grass pollen allergic patients

The clinical and immunological efficacy of preseasonal allergoid immunotherapy has been previously investigated, however, studies comparing the effectiveness of the two protocols are limited in the literature.

IgE, IgG4, IL-10, Perennial, preseasonal, RQLQ, SCIT, symptom scores

July 26, 2021

Manila grass (Zoysia matrella) Zoy m 1 allergen may contribute to allergic sensitization in tropical/subtropical regions due to extensive cross-reactivity with other group-1 grass pollen allergens

Pollen of grasses in Chloridoideae and Panicoideae subfamilies is a major source of grass group-1 allergens in tropical/subtropical areas. Previously, most studies of subtropical grass pollen allergens have focused on Cynodon dactylon (Bermuda grass-Chloridoideae) and Sorghum halepense (Johnson grass-Panicoideae). However, little information is available about allergenicity of pollen from Zoysia matrella (Manila grass or Zoysia grass-Chloridoideae), which is among the most popular turfgrasses in tropical/subtropical areas.

Allergic rhinitis, Chloridoideae, cross-reactivity, subtropical grass, Zoy m 1, Zoysia grass

July 26, 2021

Prevalence and diagnostic values of laboratory animal allergy among research personnel

Laboratory animal allergy (LAA) has not been sufficiently investigated, although LAA is a relatively common work-related condition and important occupational hazard.

Allergy, Laboratory animal, prevalence, Serum specific IgE, Skin prick test