Original Article – Page 9 – Asian Pacific Journal of Allergy and Immunology

August 7, 2022

Oleuropein attenuates inflammation and regulates immune responses in a 2,4-dinitrochlorobenzene-induced atopic dermatitis mouse model

Olive (Olea europaea Linn) leaves contain a phenolic compound oleuropein (Ole) has antioxidant, anti-inflammatory, and immunomodulatory activities. However, whether Ole might be an effective treatment for atopic dermatitis (AD) remains unknown.

allergic inflammation, atopic dermatitis, Eosinophils, IgE, mast cells, oleuropein

August 7, 2022

Systemic absorption of epinephrine compared between the intranasal and intramuscular routes of administration in healthy adults

Epinephrine 5 mg administered via the intranasal (IN) route was shown to be bioequivalent to epinephrine 0.3 mg administered via the intramuscular (IM) route in our preliminary study.

Anaphylaxis, epinephrine, intramuscular injection, intranasal administration, pharmacodynamics, pharmacokinetics

August 7, 2022

Efficacy of antimalarial agents to prevent the progression of discoid lupus erythematosus to systemic lupus erythematosus: A retrospective cross-sectional study

Discoid Lupus Erythematosus (DLE) patients have the potential to developing Systemic Lupus Erythematosus (SLE) at a later time. The prescription of antimalarial agents might be beneficial to prevent this progression but the validated data is still lacking.

Antimalarial drug, Chloroquine, Discoid lupus erythematosus, Disease progression, Hydroxychloroquine, systemic lupus erythematosus

May 30, 2022

A randomized controlled study comparing the efficacy of soap versus soap-plus-microwave disinfection for irrigation device in children with acute rhinosinusitis

Nasal irrigation is an effective component of sino-nasal disease management. Nonetheless, bacterial contamination is worrisome.

acute rhinosinusitis, bacterial contamination, microwave disinfection, nasal irrigation device, pediatric rhinosinusitis

May 30, 2022

A web-based survey on the behavior of moisturizer used in adults with and without atopic dermatitis in Thailand

Moisturizers play an important role in restoring the skin barrier. They should be used to treat and prevent eczema, especially in atopic dermatitis (AD).

atopic dermatitis, behavior, eczematous lesion, moisturizer

May 30, 2022

Anti-atopic dermatitis effect of Scutellaria barbata D. Don via regulation of MAPK signaling pathways

Atopic dermatitis (AD) is a chronic disease that causes skin itching.

atopic dermatitis, immunoglobulin E, interleukin-4, mitogen-activated protein kinase, Scutellaria barbata D. Don, trimellitic anhydride

May 30, 2022

Biological properties of reverse ankyrin engineered for dimer construction to enhance HIV-1 capsid interaction

Assembly and budding in the late-stage of human immunodeficiency virus type 1 (HIV-1) production rely on Gag protein polymerization at the inner leaflet of the plasma membrane. We previously generated a monomeric ankyrin repeat protein (Ank1D4) that specifically interacts with capsid protein (CAp24) of HIV-1, however this protein had modest binding affinity.

Ankyrin dimer, Ankyrins, Binding kinetics, Capsid proteins, HIV-1

May 30, 2022

The implementation of pediatric asthma guidelines including self-assessment of the level of confidence and accessibility of medical supplies necessary for asthma management from the perspectives of multidisciplinary care teams

Asthma control in Thai children is not yet satisfactory. Direct observation of the clinical practice for health care professionals (HCPs) in asthma clinic is essential.

asthma exacerbations, asthma guideline implementation, health care professionals, medical supplies, pediatric

May 30, 2022

Asia-Pacific survey of physicians’ perceptions and managements of chronic rhinosinusitis

The diagnosis and management of patients with chronic rhinosinusitis (CRS) may vary between otolaryngologists and allergists. Moreover, the adherence of different practitioners to European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS)2020 guideline recommendations has not been previously ascertained in Asia-Pacific regions.

allergists, chronic rhinosinusitis, diagnosis, otolaryngologists, treatment

March 14, 2022

Adverse drug reactions of montelukast and pranlukast: Analysis of the Korea database

Leukotriene receptor antagonists are recommended to treat asthma and allergic rhinitis. Although they had been used for a long time, recent studies have reported neuropsychiatric adverse drug reactions are associated with montelukast.

depression, insomnia, Leukotriene receptor antagonist, neuropsychiatric events, sleep disorder