Original Article – Page 9 – Asian Pacific Journal of Allergy and Immunology

March 14, 2022

Field sting reactions in patients receiving Hymenoptera venom immunotherapy: real-life experience

Hymenoptera stings can cause systemic allergic reactions (SARs) that are prevented by venom immunotherapy (VIT). Sting challenge tests or field stings are used to evaluate the outcome of VIT.

ACE inhibitor, adverse effects, common wasp venom, field sting, honeybee venom, Immunotherapy, Insect allergy, local allergic reaction, severity of index reaction, sting reactions, systemic allergic reaction

March 14, 2022

Particulate matter exposure during pregnancy increases risk of childhood asthma: modified by gender and NRF2 genotype

Exposure to particulate matter (PM) has been known to develop asthma in children and the oxidative stress-related mechanisms are suggested. For the development of asthma, not only the exposure dose but also the critical window and the risk modifying factors should be evaluated.

Asthma, gender, gene, NRF2, particulate matter, pregnancy

January 4, 2022

Invariant Natural Killer T (iNKT) cells response in human melioidosis

Melioidosis is an infectious disease caused by Burkholderia pseudomallei. In infected mice, IFN-γ can provide protection against B. pseudomallei infection. Invariant Natural Killer T (iNKT) cells are a subpopulation of T lymphocytes, activated by recognition of glycolipid ligands such as α-Galactosylceramide presented by CD1d, produce and secrete several cytokines, including IFN-γ and IL-4. The response of iNKT cells in human melioidosis was then investigated.

activation, Burkholderia pseudomallei, human infection, iNKT cells, Melioidosis

January 4, 2022

Role of interleukin 5-induced eosinophils in interleukin 33-triggered airway inflammation in mice

Interleukin (IL)-5 is essential for allergen induced eosinophilic airway inflammation, but not activation of T helper type 2 (Th2) cells in the lung. Although an excessive Th2 reaction is observed without IL-5 signaling, the mechanisms have remained unknown.

airway inflammation, eosinophil, IL-33, IL-5Rα-/- mice, ILC2

January 4, 2022

TGF-β1 induces epithelial-to-mesenchymal transition in chronic rhinosinusitis with nasal polyps through microRNA-182

Epithelial-to-mesenchymal transition (EMT) in nasal epithelial cells is involved in tissue remodeling of chronic rhinosinusitis with nasal polyps (CRSwNP). Our study investigated the molecular mechanisms that microRNA-182 (miR‑182) regulated EMT in eosinophilic (Eos) and non-eosinophilic (non-Eos) CRSwNP.

Eosinophilic/non-Eosinophilic chronic rhinosinusitis, Epithelial-mesenchymal transition, MicroRNA-182, nasal polyps, Transforming growth factor (TGF)-β1

January 4, 2022

Do aggravating rhinologic symptoms at work indicate occupational exposure? A cross-sectional outpatient clinic study

Air impurities can exacerbate or cause rhinologic diseases. However, only a few studies have assessed rhinologic patients’ symptoms at work.

15D, HRQoL, Rhinology, SNOT-22, work-related

January 4, 2022

A sero-epidemiological study after two waves of the COVID-19 epidemic

The COVID-19 situation in Maldives have evolved since the epidemic began in March 2020 with unprecedented increase in cases since mid-July 2019 with over 8000 cases at the end of August 2020.

age, antibody levels, COVID-19, Maldives, seroprevalence, Symptoms

November 2, 2021

Short-term immune response after inactivated SARS-CoV-2 (CoronaVac®, Sinovac) and ChAdOx1 nCoV-19 (Vaxzevria®, Oxford-AstraZeneca) vaccinations in health care workers

Inactivated SARS-CoV-2 (CoronaVac®, Sinovac, or SV) and ChAdOx1 nCoV-19 (Vaxzevria®, Oxford-Astra Zeneca, or AZ) vaccines have been administered to the health care workers (HCWs).

Anti-SARS-CoV-2 total antibody, COVID-19 vaccine, Health care workers, Inactivated SARS-CoV-2 vaccine, SARS-CoV-2 vaccine, Surrogate viral neutralizing antibody titer

November 2, 2021

Notch signaling regulates function of human mucosal-associated invariant T (MAIT) cells

Notch signaling plays an important role in the development of T lymphocytes and regulates their effector functions. The regulatory roles of Notch signaling on T cells have been intensely investigated, but whether it involves in effector functions of mucosal-associated invariant T (MAIT) cells has never been reported.

gamma secretase inhibitor, MAIT cell activation, MAIT cell function, MAIT cells, Notch signaling

November 2, 2021

Ocular manifestation and generalization after ocular onset in ocular myasthenia gravis: A 5-year analysis

Ocular Myasthenia Gravis (OMG) is an autoimmune disease which causes ptosis, diplopia, or both. There is very limited information on the presenting symptoms, treatment trends, factors influencing generalization, and treatment outcome in Thai populations.

Acetylcholinesterase inhibitors, AChR antibodies, Autoantibodies/immunology, Cholinergic/immunology, Diplopia, Generalized Myasthenia Gravis, Ocular Myasthenia Gravis, Ptosis, Receptors, Treatment outcome