Early Online – Page 7 – Asian Pacific Journal of Allergy and Immunology

August 7, 2022

Systemic absorption of epinephrine compared between the intranasal and intramuscular routes of administration in healthy adults

Epinephrine 5 mg administered via the intranasal (IN) route was shown to be bioequivalent to epinephrine 0.3 mg administered via the intramuscular (IM) route in our preliminary study.

Anaphylaxis, epinephrine, intramuscular injection, intranasal administration, pharmacodynamics, pharmacokinetics

August 7, 2022

Efficacy of antimalarial agents to prevent the progression of discoid lupus erythematosus to systemic lupus erythematosus: A retrospective cross-sectional study

Discoid Lupus Erythematosus (DLE) patients have the potential to developing Systemic Lupus Erythematosus (SLE) at a later time. The prescription of antimalarial agents might be beneficial to prevent this progression but the validated data is still lacking.

Antimalarial drug, Chloroquine, Discoid lupus erythematosus, Disease progression, Hydroxychloroquine, systemic lupus erythematosus

May 30, 2022

A randomized controlled study comparing the efficacy of soap versus soap-plus-microwave disinfection for irrigation device in children with acute rhinosinusitis

Nasal irrigation is an effective component of sino-nasal disease management. Nonetheless, bacterial contamination is worrisome.

acute rhinosinusitis, bacterial contamination, microwave disinfection, nasal irrigation device, pediatric rhinosinusitis

May 30, 2022

Anti-atopic dermatitis effect of Scutellaria barbata D. Don via regulation of MAPK signaling pathways

Atopic dermatitis (AD) is a chronic disease that causes skin itching.

atopic dermatitis, immunoglobulin E, interleukin-4, mitogen-activated protein kinase, Scutellaria barbata D. Don, trimellitic anhydride

May 30, 2022

Biological properties of reverse ankyrin engineered for dimer construction to enhance HIV-1 capsid interaction

Assembly and budding in the late-stage of human immunodeficiency virus type 1 (HIV-1) production rely on Gag protein polymerization at the inner leaflet of the plasma membrane. We previously generated a monomeric ankyrin repeat protein (Ank1D4) that specifically interacts with capsid protein (CAp24) of HIV-1, however this protein had modest binding affinity.

Ankyrin dimer, Ankyrins, Binding kinetics, Capsid proteins, HIV-1

May 30, 2022

The implementation of pediatric asthma guidelines including self-assessment of the level of confidence and accessibility of medical supplies necessary for asthma management from the perspectives of multidisciplinary care teams

Asthma control in Thai children is not yet satisfactory. Direct observation of the clinical practice for health care professionals (HCPs) in asthma clinic is essential.

asthma exacerbations, asthma guideline implementation, health care professionals, medical supplies, pediatric

May 30, 2022

Asia-Pacific survey of physicians’ perceptions and managements of chronic rhinosinusitis

The diagnosis and management of patients with chronic rhinosinusitis (CRS) may vary between otolaryngologists and allergists. Moreover, the adherence of different practitioners to European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS)2020 guideline recommendations has not been previously ascertained in Asia-Pacific regions.

allergists, chronic rhinosinusitis, diagnosis, otolaryngologists, treatment

March 14, 2022

Maintained disease control and steroid-sparing effect of subcutaneous immunotherapy in allergic rhinitis and asthma

Allergen immunotherapy is the only currently available treatment strategy that modifies the immune response to the causative allergen and induces clinical improvement and a steroid-sparing effect.

Allergen immunotherapy, Allergic rhinitis, Asthma, efficacy, inhaled steroid, intranasal steroid, steroid sparing

March 14, 2022

N-acetylcysteine potentiates the tumor cytotoxicity of cytokine-induced killer cells

Cytokine-induced killer (CIK) cells are an ex vivo expanded heterogeneous population of natural killer (NK)-like T cells that can exert potent MHC-unrestricted antitumor activity. A number of pre-clinical and clinical studies have demonstrated that CIK cells can serve as a safe and potent immunotherapy of malignant tumors. N-acetylcysteine (NAC) has been demonstrated to enhance the T-cell functions by increasing their proliferation and cytokine production.

Antitumor effect, Cancer immunotherapy, cytokine-induced killer cells, Cytotoxicity, N-acetylcysteine

March 14, 2022

Anxiety and depression are associated with reduced quality of life and increased cough severity in chronic cough

Early Online, Original Article Anxiety and depression are associated with reduced quality of life and increased cough severity in chronic cough Yiting Li,1 Chao Cao,1 Yunxin Ji,2 Suling Xu3 1 Department of Respiratory Medicine, Ningbo First Hospital, Ningbo, Zhejiang,...

Anaphylaxis, anxiety, Chronic Cough, depression, Quality of life