nattiyap@gmail.com – Page 11 – Asian Pacific Journal of Allergy and Immunology

March 14, 2022

Anxiety and depression are associated with reduced quality of life and increased cough severity in chronic cough

Early Online, Original Article Anxiety and depression are associated with reduced quality of life and increased cough severity in chronic cough Yiting Li,1 Chao Cao,1 Yunxin Ji,2 Suling Xu3 1 Department of Respiratory Medicine, Ningbo First Hospital, Ningbo, Zhejiang,...

Anaphylaxis, anxiety, Chronic Cough, depression, Quality of life

March 14, 2022

Thrombosis with thrombocytopenia after the second ChAdOx1 nCoV-19 vaccination: A possible immunological mechanism independent of anti-platelet factor 4 antibody

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a distinctive syndrome characterized by unusual site thrombosis accompanied by thrombocytopenia following adenoviral vector vaccines against severe acute respiratory syndrome coronavirus 2. Platelet-activating anti-platelet factor 4-dependent antibodies (anti-PF4 Abs) have been identified as pathogenic antibodies in almost all patients.

adenoviral vector, antibody, platelet factor 4, thromboembolism, vaccine

March 14, 2022

Field sting reactions in patients receiving Hymenoptera venom immunotherapy: real-life experience

Hymenoptera stings can cause systemic allergic reactions (SARs) that are prevented by venom immunotherapy (VIT). Sting challenge tests or field stings are used to evaluate the outcome of VIT.

ACE inhibitor, adverse effects, common wasp venom, field sting, honeybee venom, Immunotherapy, Insect allergy, local allergic reaction, severity of index reaction, sting reactions, systemic allergic reaction

March 14, 2022

Particulate matter exposure during pregnancy increases risk of childhood asthma: modified by gender and NRF2 genotype

Exposure to particulate matter (PM) has been known to develop asthma in children and the oxidative stress-related mechanisms are suggested. For the development of asthma, not only the exposure dose but also the critical window and the risk modifying factors should be evaluated.

Asthma, gender, gene, NRF2, particulate matter, pregnancy

January 4, 2022

Invariant Natural Killer T (iNKT) cells response in human melioidosis

Melioidosis is an infectious disease caused by Burkholderia pseudomallei. In infected mice, IFN-γ can provide protection against B. pseudomallei infection. Invariant Natural Killer T (iNKT) cells are a subpopulation of T lymphocytes, activated by recognition of glycolipid ligands such as α-Galactosylceramide presented by CD1d, produce and secrete several cytokines, including IFN-γ and IL-4. The response of iNKT cells in human melioidosis was then investigated.

activation, Burkholderia pseudomallei, human infection, iNKT cells, Melioidosis

January 4, 2022

Guidelines for the management of asthma in adults: Evidence and recommendations

The multidisciplinary experts in Thailand developed an asthma management recommendation that was relevant to low-middle income countries (LMICS). Population level consideration about asthma management is emphasized.

January 4, 2022

Role of interleukin 5-induced eosinophils in interleukin 33-triggered airway inflammation in mice

Interleukin (IL)-5 is essential for allergen induced eosinophilic airway inflammation, but not activation of T helper type 2 (Th2) cells in the lung. Although an excessive Th2 reaction is observed without IL-5 signaling, the mechanisms have remained unknown.

airway inflammation, eosinophil, IL-33, IL-5Rα-/- mice, ILC2

January 4, 2022

Nivolumab-induced diffuse type 2 rhinosinusitis: A case report

Nivolumab, an immune checkpoint inhibitor is used to treat advanced metastatic malignancies. Data showed that nivolumab can cause exacerbated response of T-Helper 2 cells and lead to airway inflammation.

chronic rhinosinusitis, Immune check point inhibitor, Immune-related adverse event, nasal polyps, Nivolumab, Programed cell death-ligand

January 4, 2022

TGF-β1 induces epithelial-to-mesenchymal transition in chronic rhinosinusitis with nasal polyps through microRNA-182

Epithelial-to-mesenchymal transition (EMT) in nasal epithelial cells is involved in tissue remodeling of chronic rhinosinusitis with nasal polyps (CRSwNP). Our study investigated the molecular mechanisms that microRNA-182 (miR‑182) regulated EMT in eosinophilic (Eos) and non-eosinophilic (non-Eos) CRSwNP.

Eosinophilic/non-Eosinophilic chronic rhinosinusitis, Epithelial-mesenchymal transition, MicroRNA-182, nasal polyps, Transforming growth factor (TGF)-β1

January 4, 2022

Do aggravating rhinologic symptoms at work indicate occupational exposure? A cross-sectional outpatient clinic study

Air impurities can exacerbate or cause rhinologic diseases. However, only a few studies have assessed rhinologic patients’ symptoms at work.

15D, HRQoL, Rhinology, SNOT-22, work-related