nattiyap@gmail.com – Page 13 – Asian Pacific Journal of Allergy and Immunology

November 2, 2021

Severe allergic asthma: Does alexithymia interfere with omalizumab treatment outcome?

Alexithymia is among psychological factors reported to interfere with asthma management. Severe allergic asthma (SAA) is characterized by uncontrolled asthma despite maximal standard pharmacological treatment which can benefit from an add-on treatment with Omalizumab, an anti-IgE monoclonal antibody.

alexithymia, Allergy, Asthma, Omalizumab, Quality of life

October 4, 2021

Innate immunity in COVID-19: Drivers of pathogenesis and potential therapeutic targets

A novel severe acute respiratory syndrome COVID-19 caused by coronavirus SARS-CoV-2 has been confirmed to infect more than 100 million people globally, with mortality reaching nearly 3 million as of March 2021.

COVID-19, hyperimmune activation, immunopathology, Innate immunity, SARS-CoV-2

September 20, 2021

Eosinophilia, asthma, NERD and the use of oral corticosteroids predict uncontrolled chronic rhinosinusitis with nasal polyps after surgery

Severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP) is a challenging condition to treat. The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 (EPOS2020) has the following criteria when considering biological therapy for severe uncontrolled CRSwNP: eosinophilia, need for oral corticosteroids (OCS), symptom score, loss of sense of smell and co-morbid asthma.

Asthma, chronic rhinosinusitis, computed tomography, Eosinophilia, nasal polyp, sinusitis

September 20, 2021

The role of anti-elastin antibodies in a mouse model of asthma

The role of anti-elastin antibody (Ab) in the lung is unclear, although they may be involved in chronic obstructive pulmonary disease (COPD). Recently, increased anti-elastin Ab levels were reported in asthma.

airway remodeling, Anti-elastin antibodies, Asthma, Eosinophils, TGF-β

September 20, 2021

Direct healthcare cost comparison of Fluticasone propionate/Salmeterol vs Budesonide/Formoterol Maintenance And Reliever Therapy for moderate/severe asthma: Results from Thailand

Inhaled corticosteroid/long-acting β2-agonist (ICS/LABA) for moderate/severe asthma i.e. regular Fluticasone propionate/Salmeterol (FP/Salm) with as-needed short acting beta-2 agonist (SABA) or ICS/Formoterol Maintenance And Reliever Therapy (MART) are the recommended options.

Asthma, Budesonide/Formoterol Maintenance And Reliever Therapy, Fluticasone propionate/Salmeterol, ICS/LABA, MART, Thailand

September 20, 2021

Characteristics of allergic proctocolitis in early infancy; accuracy of diagnostic tools and factors related to tolerance development

We aimed to overview clinical characteristics of FPIAP with the results of diagnostic tools like APT, SPT and fecal calprotectin levels and the factors associated with tolerance development.

allergic proctocolitis, atopy patch test, bloody stools, cow’s milk allergy, food allergy

September 20, 2021

Autologous stem cell transplantation in a patient with systemic sclerosis-associated interstitial lung disease in Taiwan

Systemic sclerosis (SSc), characterized by fibrosis of the skin and other organs, is a devastating systemic autoimmune disease. Lung involvement is frequent in SSc and contributes to the high rate of mortality.

adult stem cells, autologous transplantation, interstitial lung disease, scleroderma, systemic sclerosis, therapy

September 20, 2021

Synergy of interleukin-4 and interferon-γ in arginase-1 production in RAW264.7 macrophages

Interferon (IFN)-γ and interleukin (IL)-4 are considered to be important factors to regulate immune responses. Although the effects of IFN-γ or IL-4 on macrophage functions are well established, their cooperative action is not fully understood.

Arginase-1, interferon-γ, interleukin-4, macrophages, programmed death ligand 2

September 20, 2021

Mepolizumab improved airway hyperresponsiveness in a patient with allergic bronchopulmonary aspergillosis

Allergic bronchopulmonary aspergillosis (ABPA) is a severe type of asthma characterized by hypersensitivity to Aspergillus fumigatus and lung infiltration with eosinophilia. The central pathogenesis of asthma is airway hyperresponsiveness (AHR), with eosinophils playing a critical role. Anti-interleukin (IL)-5 antibody therapy has been recently introduced to treat severe asthma, which reportedly inactivates and reduces eosinophil count. A recent case series highlighted the improvement in asthmatic symptoms associated with ABPA, but previous reports failed to demonstrate any improvement in AHR.

ABPA, AHR, Aspergillus fumigatus, mepolizumab, Severe asthma

September 20, 2021

Adult-onset Still’s disease preceded by influenza vaccination: Coincidence or true association?

Influenza vaccine has rarely been associated with the occurrence of systemic inflammatory diseases.

adult-onset Still’s disease, arthritis, fever of unknown origin, influenza vaccination, pneumonitis