TGF-β1 induces epithelial-to-mesenchymal transition in chronic rhinosinusitis with nasal polyps through microRNA-182

Epithelial-to-mesenchymal transition (EMT) in nasal epithelial cells is involved in tissue remodeling of chronic rhinosinusitis with nasal polyps (CRSwNP). Our study investigated the molecular mechanisms that microRNA-182 (miR‑182) regulated EMT in eosinophilic (Eos) and non-eosinophilic (non-Eos) CRSwNP.
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Short-term immune response after inactivated SARS-CoV-2 (CoronaVac®, Sinovac) and ChAdOx1 nCoV-19 (Vaxzevria®, Oxford-AstraZeneca) vaccinations in health care workers

Inactivated SARS-CoV-2 (CoronaVac®, Sinovac, or SV) and ChAdOx1 nCoV-19 (Vaxzevria®, Oxford-Astra Zeneca, or AZ) vaccines have been administered to the health care workers (HCWs).
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Notch signaling regulates function of human mucosal-associated invariant T (MAIT) cells

Notch signaling plays an important role in the development of T lymphocytes and regulates their effector functions. The regulatory roles of Notch signaling on T cells have been intensely investigated, but whether it involves in effector functions of mucosal-associated invariant T (MAIT) cells has never been reported.
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Ocular manifestation and generalization after ocular onset in ocular myasthenia gravis: A 5-year analysis

Ocular Myasthenia Gravis (OMG) is an autoimmune disease which causes ptosis, diplopia, or both. There is very limited information on the presenting symptoms, treatment trends, factors influencing generalization, and treatment outcome in Thai populations.
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Ability of Alere™ HIV Combo to diagnose acute HIV infection is based mainly on HIV-1 p24 antigen detection

Alere™ HIV Combo is the only rapid and sensitive point-of-care 4th generation (antigen/antibody) HIV test newly available in Thailand which is advantageous of differentiating between positivity of antigen or antibody or both, especially in acute HIV infection (AHI). AHI in this study was defined by positive machine-based 4th generation test with measurable HIV-RNA but negative 3rd generation (IgM/IgG antibody only) tests.
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Notch 2 receptor expression and reduced cytotoxicity in MAIT cells of active pulmonary TB patients

Tuberculosis (TB) is caused by Mycobacterium tuberculosis (M.tb), resulting in significant increase in mortality rate worldwide. Immunity against M.tb consists of both innate and adaptive immunity, with emerging evidence of the role of the unconventional mucosal-associated invariant T (MAIT) cells. MAIT cells are MR1-restricted T cells that possess anti-bacterial activity, including activity in response to M.tb. To date, human studies regarding peripheral blood MAIT cell frequency and MAIT cell activity in TB patients are still controversial and most studies are cross-sectional.
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