Original Article – Page 22 – Asian Pacific Journal of Allergy and Immunology

May 27, 2019

Sensitization to house dust mite allergens might be related to the low sensitivity of ImmunoCAP to pollen allergen

Skin prick test (SPT) and ImmunoCAP are widely used to diagnose allergies. However, previous studies showed discordance between the results of SPT and ImmunoCAP and there remains a lack of research to better understand the differences in results between the two tests.

Allergy, ImmunoCAP, Perennial, Seasonal, Sensitization, Skin prick test

May 25, 2019

Patterns of sensitization to aeroallergens and their effect on airway hyper-responsiveness in Busan, Korea

Allergen sensitization and its influence on allergic disease can vary depending on ethnicity and geography.

airway hyper-responsiveness, allergens, prevalence, Sensitization, skin test

May 23, 2019

Component resolved diagnosis of walnut allergy in young children: Jug r 1 as a major walnut allergen

Walnuts (WN) are one of the main causes of tree nut allergies. However, the potential value of component resolved diagnosis (CRD) for WN allergy is controversial.

Allergy, Children, component resolved diagnosis, ISAC, Jug r 1, walnut

May 22, 2019

Prevalence of small airways dysfunction in asthma with- and without-fixed airflow obstruction and chronic obstructive pulmonary disease

Small airways dysfunction (SAD) is not uncommon in asthma without fixed airflow obstruction (FAO).

air trapping, Asthma, COPD, fixed airflow obstruction, impulse oscillometry, small airways

April 26, 2019

Anti-BP180 and anti-BP230 enzyme-linked immunosorbent assays for diagnosis and disease activity tracking of bullous pemphigoid: A prospective cohort study

Autoantibodies against BP180 and BP230 play major roles in bullous pemphigoid (BP). We are the first to describe the values of serum anti-BP180 IgG and anti-BP230 IgG enzyme-linked immunosorbent assays (ELISA) for diagnosis and disease monitoring of BP among Thai patients.

anti-BP180 ELISA, anti-BP230 ELISA, BPAG1, BPAG2, bullous pemphigoid

April 26, 2019

A simple approach to identify functional antibody variable genes in murine hybridoma cells that coexpress aberrant kappa light transcripts by restriction enzyme digestion

Specific binding to target protein epitopes by a mouse monoclonal antibody (mAb) relies on its variable domains. However, the isolation of functional variable gene transcripts is sometimes hindered by co-expression of aberrant transcripts in hybridoma cells.

Aberrant variable transcripts, chimeric antibody, dengue virus, functional variable transcripts, mouse hybridoma cells

April 22, 2019

Natural resolution of non-anaphylactic shrimp allergy in patients diagnosed 10 years earlier by oral food challenge

Shrimp allergy is considered a lifelong condition. The natural resolution of shrimp allergy is not well studied.

Allergy, food allergy, natural resolution, Oral Food Challenge, shrimp, Tolerance

April 1, 2019

The clinical significance of antinuclear antibodies and specific autoantibodies in juvenile and adult systemic lupus erythematosus patients

Juvenile systemic lupus erythematosus (JSLE) and adult SLE (ASLE) patients present with different clinical manifestations, but it is unknown if there are differences in their antinuclear autoantibody (ANA) profiles or if staining patterns are associated with specific autoantibodies and clinical manifestations.

anti-double stranded DNA, antinuclear antibodies, autoantibodies, autoimmune diseases, systemic lupus erythematosus

March 25, 2019

Association of HLA genotypes with Beta-lactam antibiotic hypersensitivity in children

Beta-lactam (BL) antibiotics hypersensitivity is common in children. Clinical manifestation of BL hypersensitivity varies from mild to severe cutaneous adverse drug reactions (SCARs).

Drug reaction, HLA-B48:01, HLA-C04:06, HLA-C08:01, HLA-DRB104:06, Thai

February 11, 2019

Down-regulation of miR-155 after treatment with narrow-band UVB and methotrexate associates with apoptosis of keratinocytes in psoriasis

Psoriasis is a chronic inflammatory skin disease arising from a complex interaction between genetics, epigenetics, the host’s immune system and the environment. Recent accumulated data revealed the dysregulation of various microRNAs (miRNAs) in several diseases including psoriasis.

apoptosis, methotrexate, miR-155, NB-UVB, psoriasis