Original Article – Page 20 – Asian Pacific Journal of Allergy and Immunology

October 22, 2019

Decrease of spleen invariant natural killer T and natural killer cell numbers in Burkholderia thailandensis-infected C57BL/6 mice

Burkholderia thailandensis is a non-pathogenic bacterium that is closely related to B. pseudomallei. Invariant natural killer T (iNKT) cells are innate lymphoid cells that play a role in bacterial infections; however the iNKT cells in B. thailandensis infections are still uncharacterized.

B. thailandensis, iNKT cells, iNKT knockout B6 mice, Melioidosis, α-GalCer

October 17, 2019

Prevalence of nasal carriage of Staphylococcus aureus in allergic rhinitis patients and healthy controls in Thailand

Staphylococcus aureus has been proposed as a disease modifier of allergic rhinitis (AR) severity. Although several studies have investigated the prevalence of nasal carriage of S. aureus in healthy controls and AR patients, data from Thailand is scarce.

allergic rhinitis patients, healthy controls, nasal carriage, prevalence, Staphylococcus aureus

October 15, 2019

Effect of vitamin D on lung function assessed by forced oscillation technique in asthmatic children with vitamin D deficiency: A randomized double-blind placebo-controlled trial

The role of vitamin D and asthma in pulmonary function changes showed conflicting result.

asthmatic children, Lung function, oscillation technique, Vitamin D

October 15, 2019

Evaluation of proteins in natural rubber latex gloves and pulmonary function amongst female nurses in two tertiary hospitals in southern, Thailand

Inhaled natural rubber latex (NRL) allergens in a healthcare environment can cause NRL sensitization and reduce pulmonary functions.

glove, nurse, protein, pulmonary function, Sensitization

September 25, 2019

Alteration of macrophage immune phenotype in a murine sepsis model is associated with susceptibility to secondary fungal infection

Secondary fungal infection is a major complication in patients with sepsis-associated immunosuppression. However, sepsis-induced immune alterations related to fungal susceptibility have not been well characterized.

CD86, immune phenotype, macrophage, PD-1, sepsis

September 22, 2019

The utility of surrogate markers in predicting HLA alleles associated with adverse drug reactions in Vietnamese

Screening for HLA-A31:01/HLA-B15:02, HLA-B57:01 and HLA-B58:01 is recommended in selected populations for prevention of carbamazepine, abacavir, and allopurinol-induced severe cutaneous adverse reactions (SCARs). Compared to conventional methods for detection of HLA alleles, PCR using a tag single nucleotide polymorphism (SNP) can be cost-effective, particularly where the surrogate marker SNP is in absolute linkage disequilibrium with the relevant HLA allele.

abacavir, allopurinol, carbamazepine, Drug Rash with Eosinophilia and Systemic Symptoms, HLA, polymorphisms, Stevens-Johnson syndrome, Toxic Epidermal Necrolysis, Vietnamese

September 18, 2019

Clinical trials of Cry j 1 and Cry j 2 T-cell epitope peptide-expressing rice in patients with Japanese cedar pollinosis

In allergic models, administration of rice that expresses a hybrid peptide consisting of 7 major T cell epitopes of Cry j 1 and Cry j 2 (7Crp), suppressed allergic symptoms, IgE elevation and specific T cell response to Japanese cedar pollen.

Cry j 1 and Cry j 2, genetically modified rice, Japanese cedar pollinosis, oral allergen immunotherapy, T cell epitope peptide

September 17, 2019

Prognostic significance of PD-L1 protein expression and copy number gains in locally advanced cervical cancer

Although immune checkpoint inhibitors against programmed death‑1 (PD‑1) and its ligand (PD‑L1) have demonstrated promising results in several solid malignancies, including cervical cancer, there are some limitations to using PD-L1 immunohistochemical expression as a predictive biomarker for selecting patients who may benefit from such therapy.

cervical cancer, copy number status, prognosis, programmed cell death-ligand 1, protein expression

September 10, 2019

Urticaria, angioedema, and type I hypersensitivity reactions associated with fibrinolytic agents

Several clinical trials of fibrinolytic agents have reported the occurrence of allergic reactions, in addition to hemorrhage. These reactions might worsen patient outcomes, especially by causing life-threatening type I hypersensitivity reactions, including anaphylaxis; however, there is a scarcity of data in this regard.

Anaphylaxis, hypotension, streptokinase, tenecteplase, tissue plasminogen activator

September 10, 2019

The quantity of unheated milk tolerated as a predictor of tolerance to baked milk

Tolerance of baked milk indicates a good prognosis in IgE-mediated cow’s milk allergy.

Allergy, Baked, Casein, Challenge, Children, Food, Milk, Predictor, Tolerance