Original Article – Page 20 – Asian Pacific Journal of Allergy and Immunology

November 5, 2019

Efficacy of a newly developed cartoon video on dry powder inhaler technique: a multicenter study

One of the factors associated with uncontrolled pediatric asthma is inadequate delivery of inhaled medication to the lungs. Incorrect inhaler technique has been reported. We developed a 2-minute cartoon video instruction aiming to improve dry powder inhaler (DPI) technique.

dry powder inhaler, inhaler techniques, multicenter study, pediatric asthma, video instruction

November 4, 2019

Intermittent hypoxia in rat enhancing peritoneal membrane thickening through HIF-1α-induced cytokines in peritoneum

Due to the high prevalence of both obstructive sleep apnea syndrome (OSA) and end-stage renal disease (ESRD), the co-existence of both conditions in peritoneal dialysis is demonstrated. Because OSA-induced chronic intermittent hypoxia is well-known, the hypoxia might worsen peritoneal membrane.

HIF-1α, intermittent hypoxia, Peritoneal dialysis, peritoneal inflammation, peritoneal membrane, sleep apnea syndrome

November 4, 2019

Diet supplementation with commercial enzymatically-hydrolyzed egg white peptides ameliorates the severity of allergy in a mouse model of egg white allergy

Commercial spray-dried egg white (S-EW) is often used for oral immunotherapy (OIT). Peptifine® (PF), a commercial preparation of enzymatically-hydrolyzed egg white (EW) peptides, is considered safe OIT food.

egg white-specific allergic mouse model, enzymatically-hydrolyzed egg white peptide (Peptifine®), Hen’s egg allergy, oral immunotherapy (OIT), spray-dried egg white (S-EW)

October 29, 2019

Clinical characteristics and aspirin desensitization in Thai patients with a suggestive history of NSAID-exacerbated respiratory disease

Non-steroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (NERD) is characterized by the triad of chronic rhinosinusitis with nasal polyp, asthma, and aspirin (ASA) or NSAID hypersensitivity. Previous study of NERD has rarely been reported in Asian population.

aspirin desensitization, Asthma, drug allergy, nasal polyp, NSAID-exacerbated respiratory disease, rhinosinusitis, sinus surgery

October 22, 2019

Decrease of spleen invariant natural killer T and natural killer cell numbers in Burkholderia thailandensis-infected C57BL/6 mice

Burkholderia thailandensis is a non-pathogenic bacterium that is closely related to B. pseudomallei. Invariant natural killer T (iNKT) cells are innate lymphoid cells that play a role in bacterial infections; however the iNKT cells in B. thailandensis infections are still uncharacterized.

B. thailandensis, iNKT cells, iNKT knockout B6 mice, Melioidosis, α-GalCer

October 17, 2019

Prevalence of nasal carriage of Staphylococcus aureus in allergic rhinitis patients and healthy controls in Thailand

Staphylococcus aureus has been proposed as a disease modifier of allergic rhinitis (AR) severity. Although several studies have investigated the prevalence of nasal carriage of S. aureus in healthy controls and AR patients, data from Thailand is scarce.

allergic rhinitis patients, healthy controls, nasal carriage, prevalence, Staphylococcus aureus

October 15, 2019

Effect of vitamin D on lung function assessed by forced oscillation technique in asthmatic children with vitamin D deficiency: A randomized double-blind placebo-controlled trial

The role of vitamin D and asthma in pulmonary function changes showed conflicting result.

asthmatic children, Lung function, oscillation technique, Vitamin D

October 15, 2019

Evaluation of proteins in natural rubber latex gloves and pulmonary function amongst female nurses in two tertiary hospitals in southern, Thailand

Inhaled natural rubber latex (NRL) allergens in a healthcare environment can cause NRL sensitization and reduce pulmonary functions.

glove, nurse, protein, pulmonary function, Sensitization

September 25, 2019

Alteration of macrophage immune phenotype in a murine sepsis model is associated with susceptibility to secondary fungal infection

Secondary fungal infection is a major complication in patients with sepsis-associated immunosuppression. However, sepsis-induced immune alterations related to fungal susceptibility have not been well characterized.

CD86, immune phenotype, macrophage, PD-1, sepsis

September 22, 2019

The utility of surrogate markers in predicting HLA alleles associated with adverse drug reactions in Vietnamese

Screening for HLA-A31:01/HLA-B15:02, HLA-B57:01 and HLA-B58:01 is recommended in selected populations for prevention of carbamazepine, abacavir, and allopurinol-induced severe cutaneous adverse reactions (SCARs). Compared to conventional methods for detection of HLA alleles, PCR using a tag single nucleotide polymorphism (SNP) can be cost-effective, particularly where the surrogate marker SNP is in absolute linkage disequilibrium with the relevant HLA allele.

abacavir, allopurinol, carbamazepine, Drug Rash with Eosinophilia and Systemic Symptoms, HLA, polymorphisms, Stevens-Johnson syndrome, Toxic Epidermal Necrolysis, Vietnamese