Original Article – Page 2 – Asian Pacific Journal of Allergy and Immunology

February 12, 2025

Neuropsychiatric adverse effects of antihistamine: A nationwide data-based epidemiological study in South Korea

Despite concerns on the major neuropsychiatric side effects for long-term use of H1-receptor antagonist (anti-histamine, AH), one of the major therapeutic tools for allergic diseases, their association has not been investigated well.

allergic diseases, Antihistamine, Drug Side Effects, Health Insurance, Psychiatric Disorders

February 12, 2025

Risk of allergic diseases in age-related macular degeneration: A nationwide cohort study in South Korea

Premorbid allergic diseases are linked with the development of age-related macular degeneration (AMD), however, the risk of allergic diseases among patients with AMD is largely unknown. Objective: To evaluate the association between AMD with or without visual disability (VD) and the risk of allergic diseases.

February 12, 2025

Understanding the uncommon: Insights into thymoma associated immunodeficiency

Thymoma-associated immunodeficiency (TAI) is a rare, acquired adult-onset immunodeficiency. It includes the classic form of Good syndrome (GS), characterized by thymoma and hypogammaglobulinemia, as well as a non-classic form of GS. This condition leads to specific or combined deficiencies in both B- and T-cells, causing considerable morbidity and mortality, although the underlying immunopathology is still not well understood.

anti-cytokine antibody, Good syndrome, hypogammaglobulinemia, immunodeficiency, thymoma

February 12, 2025

Dysbiosis involving methionine and PPAR-γ pathwaysis associated with early onset atopic dermatitis and food allergy

Atopic dermatitis (AD) and food allergy (FA) often originate early in life. Gut microbiota interactions with the host immune system influence allergy development, yet the distinct gut microbiome and functional profiles in individuals with AD, FA, or both AD+FA remain underexplored.

atopic, cohort studies, dermatitis, Food hypersensitivity, gastrointestinal microbiome, methionine, PPAR-γ, proteomics, vitamin B1

November 28, 2024

Chimeric peptides targeting the receptor-binding domainof SARS-CoV-2 variants inhibit ACE2 interaction

The receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein is pivotal in facilitating viral entry and serves as a major target for vaccine development and therapeutics. Despite undergoing mutations aimed at evading host immunity, certain regions within the RBD remain conserved.

angiotensin-converting enzyme 2 (ACE2), peptides, phage display, receptor-binding domain (RBD), respiratory disease, SARS-CoV-2

November 28, 2024

Factors associated with poor asthma control in children: A prediction model

Inhaled corticosteroids (ICS) are the first-line therapy for pediatric asthma. However, very few studies have developed simple tools for predicting treatment outcomes in pediatric asthma.

Asthma, child, Inhaled corticosteroids, prediction model, therapy

November 28, 2024

Genetic variations in Vitamin D Binding Protein (VDBP) impact vitamin D level and asthma susceptibility across the four ethnic populations

Asthma are associated with the vitamin D axis. Genetic variations of VDBP, notably rs7041 and rs4588, influence circulating vitamin D levels. However, data on their link to asthma are inconsistent, and ethnic differences remain unclear.

Asthma, cross-ethnic comparison, genetic polymorphism, Vitamin D, vitamin D binding protein

November 28, 2024

Compound D from Zingiber cassumunar Roxb. attenuatedtype 2 inflammatory cytokine-induced tight junction disruptionin airway epithelial cells

Barrier disruption in the airway mucosae has been implicated in allergic type 2 inflammatory diseases such as allergic rhinitis and asthma. Zingiber cassumunar Roxb. has long been used in traditional medicine to treat allergic diseases. The active compound, namely compound D, has proven anti-inflammatory benefits. However, the effect of compound D on allergic inflammation remains unclear.

airway epithelial cells, allergic inflammation, Asthma, tight junction, Zingiber cassumunar Roxb

November 28, 2024

Binding specificity of HuScFv to cholangiocarcinoma cells; New avenues for diagnosis and treatment

Cholangiocarcinoma (CCA) is a very aggressive cancer of the bile ducts. Recent advances in immunotherapy, particularly with human single-chain variable fragments (HuScFv), have shown promise in the treatment of solid tumors by targeting cancer cells or improving the immune response.

CCA, flow cytometry, Immunotherapy, Single-chain variable fragment, targeted cancer therapy

November 28, 2024

A 10-year comparative study of factors for allergic asthma and/or rhinitis in two cross-sectional surveys

The allergenic relevance of the living environment changes over the last decades is largely unknown.

allergic sensitization, Asthma, rhinitis, risk factor, secondhand smoke, serum IgE