Original Article – Page 11 – Asian Pacific Journal of Allergy and Immunology

July 26, 2021

Thymocytes induce renal tubular epithelial cells to undergo the epithelial-to-mesenchymal transition

Renal tubulointerstitial fibrosis is known to occur as a result of epithelial cell transformation into myofibroblasts via the epithelial-to-mesenchymal transition (EMT) process. It has been reported that macrophages, regulatory T (Treg) cells, and gamma delta T (γδ T) cells can promote fibrosis via EMT in vivo.

CD8+ T cells, Epithelial-to-mesenchymal transition (EMT), NRK-52E cells, Renal fibrosis, Thymocytes

July 26, 2021

Efficacy and safety of rupatadine fumarate in the treatment of perennial allergic rhinitis: A multicenter, double-blinded, randomized, placebo-controlled, bridging study in Koreans

The efficacy of rupatadine for the treatment of AR has been confirmed in numerous clinical studies, however there are very few studies on asian patients.

Clinical trial, Histamine antagonists, Perennial Allergic rhinitis, Platelet-activating factor, Randomized controlled trial, TNSS

July 26, 2021

Clinical characteristics and treatment outcomes of severe asthma patients with a history of multiple biologic drugs use

Asthma control has been shown to improve after clinical use of molecular-targeted biologic drugs. Although most patients have shown favorable responses to biologic drugs, some individuals need to switch to another biologic drug. To date, limited data are available regarding patients who received multiple biologic drugs.

allergic comorbidity, Allergic rhinitis, biologic drug, chronic rhinosinusitis with nasal polyps, Severe asthma

July 26, 2021

Evaluation of the clinical performance of four fungus-specific immunoglobulin E detection systems in patients with Aspergillus allergy

Allergic bronchopulmonary aspergillosis (ABPA) is an airway disease caused by Aspergillus (mainly Aspergillus fumigatus).

ABPA, Aspergillus fumigatus, fluorescence immunoassay, IgE, methodology

July 26, 2021

Prick and intradermal skin tests in patients with severe hymenoptera sting allergy using commercial versus in-house allergen extracts

Fire ant, honey bee, and wasp allergen extracts are useful in the diagnosis and treatment of severe Hymenoptera allergic patients.

Allergen extracts, Anaphylaxis, Component-resolved diagnosis, Insect allergy, Specific IgE to venom

July 26, 2021

The relationship between the rs4986791 variant of the TLR4 gene and the severity of bronchial asthma in children

Toll-like receptor 4 (TLR4) is an important receptor for lipopolysaccharide and lipid A, components of gram-negative bacteria. At present, a variant in TLR4 has been shown to be associated with asthma, but it has not been reported whether variants in TLR4 are associated with bronchial asthma in children.

bronchial asthma, Children, TLR4, variant

July 26, 2021

House dust mite SLIT-tablet is well tolerated in pediatric patients with controlled asthma

Despite the reported clinical effectiveness of house dust mite (HDM) sublingual immunotherapy (SLIT) in pediatric patients, the risk of treatment remains unclear in pediatric patients with allergic asthma.

Adverse reaction, Allergic asthma, Children, house dust mite, Sublingual immunotherapy

July 26, 2021

Are large local reactions a marker for systemic reactions to subcutaneous immunotherapy in children?

Previous studies involving predominantly adults concluded that the patients developing frequent large local reactions (LLRs) might be at greater risk for systemic reactions (SRs) during subcutaneous allergen immunotherapy (SCIT).

Children, large local reaction, pediatric, subcutaneous immunotherapy, systemic reaction

July 26, 2021

Elevation of anti-elastin antibody in patients with asthma

It is often difficult to differentiate between asthma and chronic obstructive pulmonary disease (COPD), and useful biomarkers are needed for accurate diagnosis.

airway remodeling, anti-elastin antibody, Asthma, COPD, smoking

July 20, 2021

TMAO reductase, a biomarker for gut permeability defect induced inflammation, in mouse model of chronic kidney disease and dextran sulfate solution-induced mucositis

The excretion of trimethylamine N-oxide (TMAO) (uremic toxin) into the intestine might be enhanced, due to the limited renal elimination in chronic kidney disease (CKD), possibly induced TMAO reductase (a TMAO-neutralizing enzyme) in gut bacteria. Detection of TMAO reductase in serum could be used as a biomarker of gut permeability defect.

biomarker, inflammation, kidney disease, mucositis, TMAO reductase