Early Online – Page 2 – Asian Pacific Journal of Allergy and Immunology

November 28, 2024

Chimeric peptides targeting the receptor-binding domainof SARS-CoV-2 variants inhibit ACE2 interaction

The receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein is pivotal in facilitating viral entry and serves as a major target for vaccine development and therapeutics. Despite undergoing mutations aimed at evading host immunity, certain regions within the RBD remain conserved.

angiotensin-converting enzyme 2 (ACE2), peptides, phage display, receptor-binding domain (RBD), respiratory disease, SARS-CoV-2

November 28, 2024

Factors associated with poor asthma control in children: A prediction model

Inhaled corticosteroids (ICS) are the first-line therapy for pediatric asthma. However, very few studies have developed simple tools for predicting treatment outcomes in pediatric asthma.

Asthma, child, Inhaled corticosteroids, prediction model, therapy

November 28, 2024

Genetic variations in Vitamin D Binding Protein (VDBP) impact vitamin D level and asthma susceptibility across the four ethnic populations

Asthma are associated with the vitamin D axis. Genetic variations of VDBP, notably rs7041 and rs4588, influence circulating vitamin D levels. However, data on their link to asthma are inconsistent, and ethnic differences remain unclear.

Asthma, cross-ethnic comparison, genetic polymorphism, Vitamin D, vitamin D binding protein

November 28, 2024

Compound D from Zingiber cassumunar Roxb. attenuatedtype 2 inflammatory cytokine-induced tight junction disruptionin airway epithelial cells

Barrier disruption in the airway mucosae has been implicated in allergic type 2 inflammatory diseases such as allergic rhinitis and asthma. Zingiber cassumunar Roxb. has long been used in traditional medicine to treat allergic diseases. The active compound, namely compound D, has proven anti-inflammatory benefits. However, the effect of compound D on allergic inflammation remains unclear.

airway epithelial cells, allergic inflammation, Asthma, tight junction, Zingiber cassumunar Roxb

November 28, 2024

Binding specificity of HuScFv to cholangiocarcinoma cells; New avenues for diagnosis and treatment

Cholangiocarcinoma (CCA) is a very aggressive cancer of the bile ducts. Recent advances in immunotherapy, particularly with human single-chain variable fragments (HuScFv), have shown promise in the treatment of solid tumors by targeting cancer cells or improving the immune response.

CCA, flow cytometry, Immunotherapy, Single-chain variable fragment, targeted cancer therapy

November 28, 2024

A 10-year comparative study of factors for allergic asthma and/or rhinitis in two cross-sectional surveys

The allergenic relevance of the living environment changes over the last decades is largely unknown.

allergic sensitization, Asthma, rhinitis, risk factor, secondhand smoke, serum IgE

November 28, 2024

Medication adherence, sensory attributes, and adverse effects of intranasal corticosteroids in allergic rhinitis patients: A systematic review and meta-analysis

Intranasal corticosteroid (INCS) remains the primary treatment for allergic rhinitis (AR). Understanding adherence, safety concerns and sensory preferences is crucial for optimal care.

adverse effects, Allergic rhinitis, intranasal corticosteroids, medication adherence, patient preference

April 8, 2024

Incidence, predictors, and treatment outcomes of biphasicanaphylaxis in the emergency department of a tertiary hospital: A 5-year retrospective study

Biphasic anaphylaxis despite successful treatment has an incidence of 4-5% based on NIAID/FAAN criteria. Our study aimed to investigate the frequency and predictive factors associated with biphasic reactions within the emergency department (ED) at Siriraj Hospital.

Anaphylaxis, Asia-Pacific, Biphasic anaphylaxis, drug allergy, Emergency department, food allergy, prevalence, risk factors

April 8, 2024

Lupus exacerbation in ovalbumin-induced asthmain Fc gamma receptor IIb deficient mice,partly due to hyperfunction of dendritic cells

Although allergy might be another factor that exacerbates lupus as demonstrated by several epidemiologic studies, the direct correlation between lupus activities and allergy is still in question.

Asthma, Dendritic cells, FcgRIIb, lupus, Ovalbumin, T cells

April 8, 2024

PCR combined with lateral flow dipstick assay (PCR-LFD) for a rapid diagnosis of melioidosis

Melioidosis is an infectious disease caused by Burkholderia pseudomallei. Septicemic melioidosis patients have a high mortality rate within 48 hours.

Burkholderia pseudomallei, lateral flow dipstick assay, Melioidosis, polymerase chain reaction