Immediate allergic reaction to thiocolchicoside confirmed by skin testing and basophil activation test: A case report and literature review
Eleonora Nucera,1 Riccardo Inchingolo,2 Manuela Ferraironi,3 Arianna Aruanno,1 Raffaella Chini,1 Angela Rizzi1
1 UOSD Allergologia ed Immunologia Clinica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia
2 UOC Pneumologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia
3 UOC Microbiologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia
Abstract
Background: Thiocolchicoside is a muscle relaxant, anti-inflammatory, and analgesic. Administered orally, intramuscularly, or topically, this drug is used in the symptomatic treatment of muscular spasms and rheumatologic disorders. Despite its extensive use, thiocolchicoside is a very rare sensitizer.
Objective: To evaluate IgE-mediated reaction to thiocolchicoside by basophil activation test.
Methods: Allergological work-up with skin prick tests, intradermal tests and basophil activation test with thiocolchicoside.
Results: We report the first case of immediate reaction to thiocolchicoside confirmed by basophil activation test in addition to positive skin tests.
Conclusions: BAT can be considered a complementary diagnostic tool to demonstrate an IgE-mediated reaction also for muscle relaxant drugs.
Key words: Thiocolchicoside, drug hypersensitivity, basophil activation test, immediate allergic reaction, CD63+ basophils, central muscle relaxant,