Severe cutaneous adverse drug reactions: incidence, clinical characteristics, treatment, and outcomein pediatric patients

Severe cutaneous adverse drug reactions (SCARs) can cause significant morbidity and mortality. Clinical data regarding such conditions is still limited in the pediatric population.
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The utility of surrogate markers in predicting HLA alleles associated with adverse drug reactions in Vietnamese

Screening for HLA-A31:01/HLA-B15:02, HLA-B57:01 and HLA-B58:01 is recommended in selected populations for prevention of carbamazepine, abacavir, and allopurinol-induced severe cutaneous adverse reactions (SCARs). Compared to conventional methods for detection of HLA alleles, PCR using a tag single nucleotide polymorphism (SNP) can be cost-effective, particularly where the surrogate marker SNP is in absolute linkage disequilibrium with the relevant HLA allele.
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