Severe asthma – Asian Pacific Journal of Allergy and Immunology

January 14, 2024

Differences in asthma-related outcomesby anti-IL-5 biologics, omalizumab, and dupilumabbased on blood eosinophil counts

Selecting optimal biologics based on type 2 biomarkers has been of interest in severe asthma treatment. However, few direct biomarker stratification-based comparisons have been made.

asthma biologics, eosinophil, IL-5, Severe asthma

November 12, 2023

Bronchoalveolar lavage fluid cytokines and chemokines changesafter bronchial thermoplasty in severe asthma

Bronchial thermoplasty (BT) is a non-pharmacological intervention in severe asthma with a well-known mechanism of reducing airway smooth muscle. However, its effect on airway inflammation remains uncertain.

airway inflammation, Airway smooth muscle cells, Bronchial thermoplasty, Severe asthma

September 20, 2021

Mepolizumab improved airway hyperresponsiveness in a patient with allergic bronchopulmonary aspergillosis

Allergic bronchopulmonary aspergillosis (ABPA) is a severe type of asthma characterized by hypersensitivity to Aspergillus fumigatus and lung infiltration with eosinophilia. The central pathogenesis of asthma is airway hyperresponsiveness (AHR), with eosinophils playing a critical role. Anti-interleukin (IL)-5 antibody therapy has been recently introduced to treat severe asthma, which reportedly inactivates and reduces eosinophil count. A recent case series highlighted the improvement in asthmatic symptoms associated with ABPA, but previous reports failed to demonstrate any improvement in AHR.

ABPA, AHR, Aspergillus fumigatus, mepolizumab, Severe asthma

July 26, 2021

Clinical characteristics and treatment outcomes of severe asthma patients with a history of multiple biologic drugs use

Asthma control has been shown to improve after clinical use of molecular-targeted biologic drugs. Although most patients have shown favorable responses to biologic drugs, some individuals need to switch to another biologic drug. To date, limited data are available regarding patients who received multiple biologic drugs.

allergic comorbidity, Allergic rhinitis, biologic drug, chronic rhinosinusitis with nasal polyps, Severe asthma

August 30, 2020

Is mold sensitization associated with severe asthma exacerbation in children?

Mold sensitization has been reported as a factor associated with severe asthma exacerbation (SAE).

Alternaria, asthma exacerbation, Children, mold sensitization, Severe asthma

May 25, 2020

Risk factors for poor adherence to inhaled corticosteroid therapy in patients with moderate to severe asthma

Poor adherence to inhaled corticosteroid (ICS) therapy is a common reason for worsened asthma control.

Adherence, Age at onset, Asthma, Difficult-to-control asthma, Inhaled corticosteroids, risk factor, Severe asthma