Articular involvement in Henoch-Schönlein Purpura: A review of literature
Victor Gonzalez-Uribe,1,2 Ricardo Martínez-Tenopala,2 Ana Paula Solórzano-Anduiza,2 María Fernández-De La Torre,2 Zaira S. Mojica-Gonzalez3
Affiliations:
1 Pediatric Allergy & Clinical Immunology Department, Hospital Infantil de Mexico Federico Gomez
2 Facultad Mexicana de Medicina, Universidad La Salle Mexico City, Mexico
3 Pathology, Molecular Biology, and Immunohistochemistry, Hospital General de Mexico, Dr Eduardo Liceaga, Mexico City, Mexico
Abstract
Background: Henoch-Schönlein purpura (HSP), the most typical kind of pediatric vasculitis, can also affect adults. Over the last 10 years, research has been increasing on improvements in HSP diagnosis, physiopathology, symptoms, and therapy. Joint involvement is highly frequent in this condition; however, it typically undergoes spontaneous resolution and does not lead to long-term complications.
Objective: To provide a deeper understanding of the constituting pathogenic mechanisms and clinical presentation of articular involvement, focusing on the effect of neutrophil activation on systemic small vessels.
Methods: This literature review utilized a systematic search of academic databases, employing specific keywords to select recent peer-reviewed articles and scholarly sources on the topic.
Results: The manifestations of joint involvement in HSP can vary in severity and frequency. Non-steroidal
anti-inflammatory medications or acetaminophen are considered the first-line treatment for joint pain; however, corticosteroids may help achieve quick remission. In cases where standard treatment fails or manifestations persist, immunosuppressive drugs like rituximab, methotrexate, cyclophosphamide, or azathioprine have been used.
Conclusions: While it tends to resolve without lasting joint damage, accurate diagnosis and appropriate management are crucial to ensure optimal patient outcomes.
Key words: IgA vasculitis, arthralgia, arthritis, treatment, physiopathology, Henoch – Schoenlein purpura