Original Article – Page 20 – Asian Pacific Journal of Allergy and Immunology

September 25, 2019

Alteration of macrophage immune phenotype in a murine sepsis model is associated with susceptibility to secondary fungal infection

Secondary fungal infection is a major complication in patients with sepsis-associated immunosuppression. However, sepsis-induced immune alterations related to fungal susceptibility have not been well characterized.

CD86, immune phenotype, macrophage, PD-1, sepsis

September 22, 2019

The utility of surrogate markers in predicting HLA alleles associated with adverse drug reactions in Vietnamese

Screening for HLA-A31:01/HLA-B15:02, HLA-B57:01 and HLA-B58:01 is recommended in selected populations for prevention of carbamazepine, abacavir, and allopurinol-induced severe cutaneous adverse reactions (SCARs). Compared to conventional methods for detection of HLA alleles, PCR using a tag single nucleotide polymorphism (SNP) can be cost-effective, particularly where the surrogate marker SNP is in absolute linkage disequilibrium with the relevant HLA allele.

abacavir, allopurinol, carbamazepine, Drug Rash with Eosinophilia and Systemic Symptoms, HLA, polymorphisms, Stevens-Johnson syndrome, Toxic Epidermal Necrolysis, Vietnamese

September 18, 2019

Clinical trials of Cry j 1 and Cry j 2 T-cell epitope peptide-expressing rice in patients with Japanese cedar pollinosis

In allergic models, administration of rice that expresses a hybrid peptide consisting of 7 major T cell epitopes of Cry j 1 and Cry j 2 (7Crp), suppressed allergic symptoms, IgE elevation and specific T cell response to Japanese cedar pollen.

Cry j 1 and Cry j 2, genetically modified rice, Japanese cedar pollinosis, oral allergen immunotherapy, T cell epitope peptide

September 17, 2019

Prognostic significance of PD-L1 protein expression and copy number gains in locally advanced cervical cancer

Although immune checkpoint inhibitors against programmed death‑1 (PD‑1) and its ligand (PD‑L1) have demonstrated promising results in several solid malignancies, including cervical cancer, there are some limitations to using PD-L1 immunohistochemical expression as a predictive biomarker for selecting patients who may benefit from such therapy.

cervical cancer, copy number status, prognosis, programmed cell death-ligand 1, protein expression

September 10, 2019

Urticaria, angioedema, and type I hypersensitivity reactions associated with fibrinolytic agents

Several clinical trials of fibrinolytic agents have reported the occurrence of allergic reactions, in addition to hemorrhage. These reactions might worsen patient outcomes, especially by causing life-threatening type I hypersensitivity reactions, including anaphylaxis; however, there is a scarcity of data in this regard.

Anaphylaxis, hypotension, streptokinase, tenecteplase, tissue plasminogen activator

September 10, 2019

The quantity of unheated milk tolerated as a predictor of tolerance to baked milk

Tolerance of baked milk indicates a good prognosis in IgE-mediated cow’s milk allergy.

Allergy, Baked, Casein, Challenge, Children, Food, Milk, Predictor, Tolerance

September 10, 2019

Effect of gene polymorphisms in ADAM33, TGFβ1, VEGFA, and PLAUR on asthma in Thai population

Most of the asthma susceptibility genes have demonstrated moderate effect. Gene-gene interaction may play a role in asthma.

ADAM33, Asthma, gene interactions, Gene polymorphisms, PLAUR, TGFβ1, Thai population, VEGFA

August 19, 2019

The association of plasma cytokines including VEGF with recurrent wheezing in allergic patients

Various cytokines have been studied to determine their functions in the pathogenesis of allergic diseases and their potential as therapeutic targets, but the roles and clinical applicability of many of these cytokines still remain unclear.

Allergic disease, CCL2/MCP-1, PDGFBB, Recurrent wheezing, VEGF

August 13, 2019

Food sensitization and food allergy in allergic Thai patients from a tertiary care center in Thailand

A skin prick test (SPT) and food challenge test (OFC) are useful in identification of food sensitization and food allergy.

allergic patients, food allergy, food sensitization, oral food challenge test, Skin prick test

August 3, 2019

Effect of Hatha yoga training on rhinitis symptoms and cytokines in allergic rhinitis patients

Allergic rhinitis is an inflammation of the nasal mucosa in response to allergens. There is evidence that yoga can improve personal health and has positive effects on immune function. However, the effects of Hatha yoga training on rhinitis symptoms and cytokines in patients with allergic rhinitis are still unclear.

Allergic rhinitis, cytokine, Nasal blood flow, Peak nasal inspiratory flow, Yoga