Original Article – Page 16 – Asian Pacific Journal of Allergy and Immunology

July 18, 2020

A pilot study into bosentan (Tracleer®) as an immunomodulating agent in patients with Behçet’s disease

Behçet’s disease (BD) is an auto-inflammatory vasculitis characterized by aphthous oro-genital ulcers, inflammatory skin changes and uveitis. Treatment is mainly immunosuppressive. Interestingly, elevated endotheline-1 (ET-1) levels suggest a possible beneficial effect of treatment with an ET-1 receptor antagonist.

BDCAF, Behçet’s disease, bosentan, treatment, trial

July 15, 2020

Validation and reliability of the Thai version of the Food Allergy Quality of Life Questionnaire-Parent Form (FAQLQ-PF)

Food allergy has an impact on the quality of life of both patients and caregivers. It is, therefore, important to have a native language survey to evaluate health-related quality of life (HRQL) among food allergic children.

Food hypersensitivity, Pediatrics, Quality of life, Questionnaire, Thai

July 13, 2020

The effect of vitamin D add-on therapy on the improvement of quality of life and clinical symptoms of patients with chronic spontaneous urticaria

Chronic urticaria is a common distressing allergic skin disorder. Immune dysregulation, histamine release and mast cell degranulation are suggested as its underlying mechanisms.

Add-on Therapy, Chronic Urticaria, Clinical symptoms, Quality of life, Vitamin D

July 13, 2020

Efficacy, patients’ perception, and cost of medication in allergic rhinitis with subcutaneous immunotherapy

Allergic rhinitis (AR) is the allergic inflammation of nasal mucosa. Treatment of AR includes pharmacotherapy and allergen immunotherapy. Subcutaneous immunotherapy (SCIT) is indicated in inadequate disease control, patient’s preference, or impossible allergen avoidance. SCIT is an effective treatment but its cost is comparatively high. Efficacy, patient perception, and cost of medication are rarely explored in Asia.

cost-benefit, efficacy, Immunotherapy, perception, safety

June 29, 2020

Regional differences in the prevalence of oral allergy syndrome among Japanese children: A questionnaire-based survey

Oral allergy syndrome (OAS) is characterized by an immediate allergic reaction that mainly or partially affects the oral mucosa, pharynx, or lips, and it is usually caused by ingesting fresh fruits or vegetables. Most patients with OAS also have allergic rhinitis due to pollen. As allergic rhinitis is increasingly prevalent in the Japanese population and the age at disease development is decreasing, morbidity associated with OAS among the younger population is likely to increase. However, there is little information about the prevalence of this disease among Japanese children, specifically the influences of residency in regions with different environments.

Allergic rhinitis, child, oral allergy syndrome, pollen-food allergy syndrome, prevalence

June 23, 2020

MicroRNA-21 in plasma exosome, but not from whole plasma, as a biomarker for the severe interstitial fibrosis and tubular atrophy (IF/TA) in post-renal transplantation

Non-invasive diagnosis of interstitial fibrosis and tubular atrophy (IF/TA), a major cause of chronic allograft dysfunction in post-kidney transplantation (post-KT), is needed.

Exosome, Interstitial Fibrosis, Kidney transplantation, MicroRNA, Tubular Atrophy

June 15, 2020

A randomized, double-blind, placebo-controlled trial on the effect of intranasal corticosteroid as a treatment for moderate to severe obstructive sleep apnea with coexisting chronic rhinitis

Chronic rhinitis is a common co-existing disease with obstructive sleep apnea (OSA). Current evidence on intranasal steroid efficacy as a treatment modality is scarce.

chronic rhinitis, intranasal corticosteroid, obstructive sleep apnea, oral appliance, positional therapy

May 25, 2020

Risk factors for poor adherence to inhaled corticosteroid therapy in patients with moderate to severe asthma

Poor adherence to inhaled corticosteroid (ICS) therapy is a common reason for worsened asthma control.

Adherence, Age at onset, Asthma, Difficult-to-control asthma, Inhaled corticosteroids, risk factor, Severe asthma

May 25, 2020

Distinct effects of different adjuvants in the mouse model of allergic airway inflammation

Allergic asthma was typically considered as an inflammatory disease mediated by type 2 immunity. However, recent studies revealed that asthma is a complex disease displaying a variety of phenotypes and endotypes.

Adjuvants, Allergy, Asthma, inflammation, Lung

May 25, 2020

A new trend in sensitization to cockroach allergen: A cross-sectional study of indoor allergens and food allergens in the inland region of Southwest China

Despite the increasing prevalence of allergic disease, large-scale studies to investigate allergen sensitization have rarely been conducted in the inland region of Southwest China.

allergic diseases, cockroach allergen, food allergen, polysensitization patterns, Specific IgE