Case Report – Asian Pacific Journal of Allergy and Immunology

May 30, 2022

Skin necrosis following local anesthetic: Same presentation for two different diagnoses

Local anesthetics (LA) are widely used in medicine and are generally well tolerated. Although most adverse reactions are nonallergic, LA are a frequent reason for allergy consultation.

drug allergy evaluation, Drug hypersensitivity, local anesthetic hypersensitivity, local anesthetics, skin necrosis

March 14, 2022

Thrombosis with thrombocytopenia after the second ChAdOx1 nCoV-19 vaccination: A possible immunological mechanism independent of anti-platelet factor 4 antibody

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a distinctive syndrome characterized by unusual site thrombosis accompanied by thrombocytopenia following adenoviral vector vaccines against severe acute respiratory syndrome coronavirus 2. Platelet-activating anti-platelet factor 4-dependent antibodies (anti-PF4 Abs) have been identified as pathogenic antibodies in almost all patients.

adenoviral vector, antibody, platelet factor 4, thromboembolism, vaccine

January 4, 2022

Nivolumab-induced diffuse type 2 rhinosinusitis: A case report

Nivolumab, an immune checkpoint inhibitor is used to treat advanced metastatic malignancies. Data showed that nivolumab can cause exacerbated response of T-Helper 2 cells and lead to airway inflammation.

chronic rhinosinusitis, Immune check point inhibitor, Immune-related adverse event, nasal polyps, Nivolumab, Programed cell death-ligand

January 4, 2022

Concomitant chronic spontaneous urticaria treatment might hinder the diagnosis of occupational latex-induced anaphylaxis: A case report

Cutaneous manifestations of chronic spontaneous urticaria (CSU) are identical to type 1 hypersensitivity reactions. The daily occurrence of rash from occupational allergy could be misinterpreted as CSU exacerbation.

Anaphylaxis, Drug hypersensitivity, hypersensitivity, latex hypersensitivity, natural rubber latex, nursing, skin tests, urticaria

September 20, 2021

Autologous stem cell transplantation in a patient with systemic sclerosis-associated interstitial lung disease in Taiwan

Systemic sclerosis (SSc), characterized by fibrosis of the skin and other organs, is a devastating systemic autoimmune disease. Lung involvement is frequent in SSc and contributes to the high rate of mortality.

adult stem cells, autologous transplantation, interstitial lung disease, scleroderma, systemic sclerosis, therapy

September 20, 2021

Mepolizumab improved airway hyperresponsiveness in a patient with allergic bronchopulmonary aspergillosis

Allergic bronchopulmonary aspergillosis (ABPA) is a severe type of asthma characterized by hypersensitivity to Aspergillus fumigatus and lung infiltration with eosinophilia. The central pathogenesis of asthma is airway hyperresponsiveness (AHR), with eosinophils playing a critical role. Anti-interleukin (IL)-5 antibody therapy has been recently introduced to treat severe asthma, which reportedly inactivates and reduces eosinophil count. A recent case series highlighted the improvement in asthmatic symptoms associated with ABPA, but previous reports failed to demonstrate any improvement in AHR.

ABPA, AHR, Aspergillus fumigatus, mepolizumab, Severe asthma

September 20, 2021

Adult-onset Still’s disease preceded by influenza vaccination: Coincidence or true association?

Influenza vaccine has rarely been associated with the occurrence of systemic inflammatory diseases.

adult-onset Still’s disease, arthritis, fever of unknown origin, influenza vaccination, pneumonitis

July 26, 2021

Successful treatment of atopic dermatitis with house dust mite sublingual immunotherapy tablets

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. Allergen-specific immunotherapy is a treatment option for selected patients with severe AD sensitization to house dust mites (HDM).

allergen-specific immunotherapy, atopic dermatitis, house dust mites, SCORAD, SLIT

July 26, 2021

A rare case of chlorhexidine- and clindamycin-induced anaphylaxis

Chlorhexidine and clindamycin, especially the latter, rarely cause anaphylaxis.

Anaphylaxis, Chlorhexidine, clindamycin, provocation test, β-lactam antibiotics

July 26, 2021

Immunohistochemical characterization of granulomatosis with polyangiitis exhibiting spontaneous regression

Granulomatosis with polyangiitis (GPA) is characterized by granulomatous inflammation, vasculitis, and elevated levels of serum proteinase 3 (PR3)-anti-neutrophil cytoplasmic antibody (PR3-ANCA).

Granulomatosis with Polyangiitis, Immunohistochemistry, Lung, PR3-ANCA, Spontaneous Regression