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Case Report
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Successful treatment of atopic dermatitis with house dust mite sublingual immunotherapy tablets

July 26, 2021
Case Report

Successful treatment of atopic dermatitis with house dust mite sublingual immunotherapy tablets

Ploykarn Kiatiwat,1 Wat Mitthamsiri,1 Tadech Boonpiyathad,1 Panitan Pradubpongsa,1 Atik Sangasapaviliya1

1 Division of Allergy and Clinical Immunology, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand

Abstract

Background: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. Allergen-specific immunotherapy is a treatment option for selected patients with severe AD sensitization to house dust mites (HDM).
Objective: To report the first case of successful treatment with HDM sublingual immunotherapy (SLIT) tablets in patients with severe AD.
Method: A Thai male patient with HDM sensitization and severe AD who had not responded to topical corticosteroids and calcineurin inhibitors underwent 1 month of HDM subcutaneous immunotherapy (SCIT), after which his skin symptoms were minimally improved. He lost follow-up SCIT and the symptoms worsened, with large wheal lesions appearing at the SCIT injection site, so we decided to switch from SCIT to HDM SLIT tablets.
Results: After the SLIT treatment, the AD and skin lesions improved and the medication could be stopped.
Conclusion: HDM SLIT might be an alternative treatment in patients with HDM sensitization and severe AD who are refractory to conventional treatment.
Key words: house dust mites, allergen-specific immunotherapy, atopic dermatitis, SLIT, SCORAD

Full Text
allergen-specific immunotherapy, atopic dermatitis, house dust mites, SCORAD, SLIT

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allergen Allergic rhinitis Allergy Anaphylaxis Asthma atopic dermatitis child Children Chlorhexidine chronic rhinosinusitis chronic spontaneous urticaria Chronic Urticaria COVID-19 cytokine depression diagnosis drug allergy Drug hypersensitivity efficacy Epidemiology food allergy Food hypersensitivity house dust mite IgE Immunotherapy obstructive sleep apnea Omalizumab prevalence primary immunodeficiency Quality of life Questionnaire Reliability risk factor risk factors safety SARS-CoV-2 Sensitization Severe asthma Skin prick test Specific IgE Thai treatment urticaria vaccine Vitamin D
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